By Joseph C. Arcos, Yin-Tak Woo, Mary F. Argus
Chemical Induction of melanoma: Structural Bases and organic Mechanisms quantity IIIA bargains with the natural and biochemical ideas at the back of cancer.
This quantity includes the continuation of quantity IIA, which tackles structure-activity relationships of chemical cancer causing agents, the impact of chemical reactivity, molecular geometry, and metabolism on carcinogenic job. less than this is often non-conjugated natural compounds.
The textual content is suggested for medical professionals, natural chemists, and biochemists with a sophisticated wisdom in biochemistry and natural chemistry and wish to comprehend extra the biochemical techniques of melanoma.
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Additional info for Aliphatic Carcinogens. Structural Bases and Biological Mechanisms
The high volatility of bis(chloromethyl) ether and chloromethyl methyl ether and their extensive industrial uses have prompted many investigators to examine their carcinogenicity by inhalation. The major findings of these studies are sum marized in Table XVI. Leong et al. (98) were the first to test the inhalation carcinogenicity of these compounds. Strain A/Heston male mice, which are known to be highly responsive to pulmonary tumor induction with a spontaneous incidence of about 40%, were used in this study.
From these studies, three salient features of structure-activity relationships were observed: 1. , chloromethyl methyl ether). 2. The carcinogenic activity of chloroalkyl ethers decreases as chlorine moves further away from the ether oxygen. , bis(a-chloroethyl) ether]. 3. The carcinogenic activity decreases as the alkyl chain length increases. For example, if one considers bis(chloromethyl) ether, bis-l,2-(chloromethoxy)ethane, bis-l,4-(chloromethoxy)butane, and bis-1,6-(chloromethoxy)hexane as a homologous series of di-a-chloro ethers of increasing length, it is clear that in general the longer the chain length, the lower the carcinogenicity.
M . Goldschmidt, and I. Seidman [Cancer R e s . 35, 2553 (1975)]. 1 Carcinogenic Cross-Linking Agents and Alkyl Donors series of studies. -xylene, and tris-l,2,3-(chloromethoxy)propane were found active as complete carcin ogens. Most of the other compounds tested were active as initiators. From these studies, three salient features of structure-activity relationships were observed: 1. , chloromethyl methyl ether). 2. The carcinogenic activity of chloroalkyl ethers decreases as chlorine moves further away from the ether oxygen.